Durban - The Springboks had to draft Sharks lock Alistair Hargreaves into their starting 15 for Saturday's Tri-Nations Series Test against Australia in Sydney.
Hargreaves replaces Johann Muller, who was ruled out after further evaluation on his hamstring strain during training.
Muller had not recovered sufficiently to take his place in the team.
Props Dean Greyling, Werner Kruger and looseforward Ashley Johnson will make their international debut on Saturday.
"The new caps had outstanding Super Rugby seasons and this is an exciting opportunity for them. They have been rewarded for their form and now it's up to them," said Bok coach Peter de Villiers.
The world champions will be led by John Smit, in his 103rd Test and the skipper is confident that the two newbies (Greyling and Kruger) will fit well into South Africa's front row.
"We have got some new combinations, but there is a lot of potential in this side and the players are hungry for this chance," added De Villiers.
Heinrich Brussow was not considered as he continues his rehabilitation from a knee injury while the experienced trio of halfbacks Ruan Pienaar and Morne Steyn and inside centre Wynand Oliver complete the backline.
The South Africans are prepared for a fiery Australian side whom will be looking to make up for their 32-23 loss to Samoa. Seven regular Wallabies were missing from Sunday's defeat.
Squads:
South Africa: 15 Gio Aplon; 14 Bjorn Basson, 13 Juan De Jongh, 12 Wynand Olivier, 11 Lwazi Mvovo; 10 Morne Steyn, 9 Ruan Pienaar; 8 Ashley Johnson ,7 Danie Rossouw, 6 Deon Stegmann; 5 Alistair Hargreaves, 4 Flip van der Merwe; 3 Werner Kruger, 2 John Smit (capt), 1 Dean Greyling
Substitutes: 16 Chiliboy Ralepelle, 17 CJ van der Linde, 18 Ryan Kankowski, 19 Jean Deysel, 20 Charl McLeod, 21 Adrian Jacobs, 22 Patrick Lambie
Australia: 15 Kurtley Beale; 14 James O'Connor, 13 Adam Ashley-Cooper, 12 Pat McCabe, 11 Digby Ioane; 10 Quade Cooper, 9 Will Genia; 8 Ben McCalman, 7 David Pocock, 6 Rocky Elsom (capt); 5 James Horwill, 4 Rob Simmons; 3 Ben Alexander, 2 Stephen Moore, 1 Sekope Kepu
Substitutes: 16 Saia Faingaa, 17 Pekahou Cowan, 18 Nathan Sharpe, 19 Matt Hodgson, 20 Scott Higginbotham, 21 Nick Phipps, 22 Anthony Faingaa.
